Global Development Politics Policy Brief Essay Example | Topics and Well Written Essays - 1250 words

Global Development Politics Policy Brief - Essay Example How can the international society continue to maintain sustainable development of its population without inducing further effects of climate change? This question continues to remain a nightmare to experts in environment and economist, alike. Experts mandated to ensure practical climate change policies face this similar challenge. The policy options identified, discussed and proposed include applying costs and benefits analysis exhibition to the public. This, in turn, would inform the public on the effects of climate change on health and environment including the economy. Analysis and exhibition of climate change effects would evoke initiatives for early mitigation of climate change among the population. The second proposal is to ensure reduced level of emissions, on a global scale, would help address climate change. These include agreement on acceptable amount emitted by countries (Posner & Weisbach 2010, p.3). The third proposal is to find means that would change the human behavior and help reduce human causes of this global environmental threat. To sustain the ever-escalating human population growth rate and the ability to support their demands for natural resources, without inducing climate change-causing processes, we recommend initiatives that would correct human norms and behavior to control development. Situation brief Why should the world address climate change? The apparent pursuit to implement sustainable development raises concerns on the necessity to have a succinct policy regulation that control developmental effects. World organizations including institutions sets up by the United Nations face the challenge of ensuring developments that guarantee an uncompromised future. Climate change is among the major challenges that are at the focus of issues that call for redress and attention from the world community, through a united approach. Most conventions and treaties set by international bodies, since the 1972 meeting at Stockholm have climate change as one of the priority challenges. The scope of climate change implications on diverse sectors including the economy, food production and health makes it a grim issue that is better when addressed than left to escalate. Noteworthy is the concern that climate change implications are not region-specific but a matter that is all-inclusive of the entire world society. Scientists point at an alarming change in world temperatures and an anticipation of potential increase in ice melt rate. What are the challenges to existing climate change control policies? Existing policy initiatives to control the rate of emission have little, so to say, effectiveness. The policy frameworks available to suppress over emission from development activities, in developed countries especially, have failed. The carbon credit initiatives tend to assure the world population of insignificant influence and effects. Climate finance is another unsuccessful idea that has least impact in controlling climate change. T he current situation calls for a workable framework that would leave the world population staying in a clean atmosphere that is free of contamination and related effects. The high extent of uncertainty in predicting possible impacts of the alteration of world climatic conditions is the key threat to existing policies. Policy discussion Climate change economists

Benefits of Pets Essay Example for Free

Benefits of Pets Essay 1. Decreases stress In a 2002 study at State University of New York at Buffalo, researchers found that when conducting a stressful task, people experienced less stress when their pets were with them than when a spouse, family member or close friend was nearby. Promises Treatment Centers, which specializes in addiction, not only recommends its patients consider getting a pet, but even allows pets in its rehabilitation facilities, according to Dr. David Sack, CEO of Promises. â€Å"One of Promises core beliefs is that we need to remove obstacles that prevent people from getting help,† Sack says. â€Å"We are committed to making Promises a safe and reassuring homelike environment. And what could be more like home than to have your pet accompany you?† 2. Lowers blood pressure While some studies have found a stronger connection than others, having a pet has the potential to lower blood pressure, especially in hypertensive or high-risk patients, according to the Centers for Disease Control and Prevention (CDC). â€Å"If you have a dog around, your blood pressure is lower,† says Marty Becker, DVM, veterinary consultant for Good Morning America and author of the upcoming book, Your Dog: The Owner’s Manual. â€Å"A lot of it goes back to reducing stress: You might lose your job, your house, your 401(k) — but you’ll never lose the unconditional love of your pet.† 3. Eases pain Believe it or not, pets can be the best medicine, especially when a person is dealing with chronic pain such as migraines or arthritis, says Becker. â€Å"Just like Valium, it reduces anxiety. The less anxiety, the less pain,† he says. â€Å"Some studies about acute pain actually found that adults who used pet therapy required 50 percent less pain medication than those who did not.† 4. Lowers cholesterol According to the CDC, another heart-healthy result of owning a pet is lower cholesterol. â€Å"They lower cholesterol by about five points,† says Becker. It isn’t clear whether the pet’s presence decreases cholesterol, or if those who maintain a healthier lifestyle are more often pet owners. However, it is known that male pet owners, in particular, have lower triglyceride and cholesterol levels than non–pet owners. 5. Improves mood A lot of the health benefits of owning a pet may stem from the mental and emotional benefits. â€Å"People who have pets are less harried; there’s more laughter in their life,† says Becker. â€Å"When you come home, it’s like you’re George Clooney. You’re a star.† This is a primary reason pets are used in various forms of therapy. â€Å"At Walter Reed Army Medical Center, they’re using dogs to help soldiers dealing with post-traumatic stress disorder,† says Katy Nelson, DVM, associate emergency veterinarian at the VCA Alexandria Animal Hospital in Alexandria, Va. â€Å"They’re finding the guys who have a pet are able to re-enter society a little bit easier. They’re showing a decreased suicide rate, one of the biggest health threats [veterans] face. These guys who have a pet have someone they’re responsible for, someone who cares about them. And they don’t have to explain what they’ve been through.† 6. Helps people socialize While it may seem a bit counterintuitive, owning a dog actually increases a person’s opportunities to socialize, according to Michael Landa, CEO of natural pet food brand Nulo and founder of Los Angeles–based dog-walking service The Pet Staff. â€Å"I take my dog for a two-mile walk every day, and I run into five to 10 people whom I stop and talk to,† he says. Christie Keith, the online and social media editor at PetConnection.com, agrees. A 1999 Canadian study found that pet owners were more socially engaged than non–pet owners, she says. In addition, an Austrian study â€Å"found that pet ownership led to an increase in social contact, more socialization within neighborhoods [such as neighbors chatting as they walk their dogs], and even a greater perception to observers that the neighborhood seems friendly.’† 7. Prevents strokes Although dogs are often touted for their health benefits, cat owners can see gains, too. Felines are just as beneficial to your health as dogs. â€Å"If you have a cat, you’re 30 percent less likely to have a heart attack, and you’re 40 percent less likely to have a cardiovascular incident like a stroke,† Becker says. In addition, pets can aid in the recovery of a heart attack. â€Å"If you have a heart attack and you have a dog, you are eight times more likely to be alive a year later,† Becker says. 8. Monitors blood sugar levels for diabetics According to the American Diabetes Association’s Diabetes Forecast magazine, a 1992 study found that one-third of the pets living with diabetics (mostly dogs, but other pets included cats, birds and rabbits) would change their behavior when their owner’s blood sugar level dropped. Most likely a reaction to chemical changes in the owner’s body, the behavior noted in the study has resulted in organizations like Dogs4Diabetics, which trains dogs to be companions for patients at risk of unstable blood glucose levels. 9. Prevents allergies and improves immunity Becker says pets can dramatically improve immunity and prevent allergies. â€Å"A study found that children ages 5 to 7 from pet-owning households attend school three weeks more per year than those who don’t have pets,† he says. He also says that the more pets you have earlier in life, the fewer allergies you will develop. â€Å"Kids who grow up on farms and around animals don’t have allergies,† he says. â€Å"That dander on that hair, that’s natural immunotherapy.† But he notes that this effect is not reversible: Getting a pet as an adult will not minimize allergies, it only helps prevent certain allergies from developing in children. 10. Helps children develop Children who grow up in a household with pets benefit in myriad ways, especially in their emotional development. â€Å"When a child is attached to a dog or cat, they learn to express themselves in more ways and they learn to relate better,† says Landa, who brings children to animal shelters to deliver toys and food. Pets are also hugely beneficial to children suffering from autism and Attention Deficit Hyperactivity Disorder (ADHD). For children with ADHD, taking care of a pet can encourage them to focus on responsibilities through a predictable routine. While the sensory experience of holding and petting an animal can be soothing for children with autism.

Secretors And Non Secretors In Human Population Antigens Biology Essay

Secretors And Non Secretors In Human Population Antigens Biology Essay Human population can be categorized into secretors and non-secretors based on A, B and H antigen on basis of presence or absence of these blood group antigens in the body fluids and secretions, such as saliva, sweat, tears, semen, serum, mucus present in the digestive tract or respiratory cavities etc. Secretors are individuals that secrete blood group antigens in their body fluids while non-secretors are the individuals that do not secrete them in their body fluids and secretions. It is a known fact that ABO blood type is controlled by blood type coding genes present on the chromosome 9q34 but the secretor status of an individual is decided by interaction of a separate gene (called secreting gene) with these blood type genes. The presence of the secreting gene in a persons genome makes him a secretor and absence makes him a non secretor. The gene is designated as (Se) for Secretors and (se) for Non-secretors and it is entirely independent of the blood type A, B, AB or O. The individuals secreting antigens in the body fluid are designated as ABH secretors in blood banks. Individuals having O blood group secrete antigen H, A blood group secrete A and H antigens, B blood group secrete B and H antigens in the fluids. A secretor gene helps a person to gain a degree of protection against different environmental conditions especially the micro flora of a particular environment and also the lectins present in them. It helps them in promoting the growth of friendly, stable blood type intestinal bacterial ecosystem which depends on the blood type antigens present in the mucus of an individual. Secretor status does modify carbohydrates in the fluids present in the body and their secretions and it also affects and influences the attachment and persistence of the micro flora present in the body. Secretors are at a higher advantage than non-secretors. Non-secretors have a potential health disadvantage. They possess many metabolic traits such as carbohydrate intolerance, immune susceptibilities. Different tests are available for determining an individuals secretor status. Most common test uses saliva or other body fluids of an individual for testing the secretor status. These tests are based on the principl e of Agglutination Inhibition where the antigens are neutralized by the corresponding antibodies so that these antibodies will not be further be available to neutralize or agglutinate the same antigens residing on the red blood cells. ELISA could also be used for determining the presence of the secreted Lewis antigens in the saliva or other body fluids. Statistics 1 Place Population Tested % Secretor Frequency % Non-Secretor Frequency New York Negroes 178 61.2 0.38 38.8 0.62 Copenhagen Danes 263 74.0 0.49 26.0 0.51 Japan Japanese 424 75.7 0.51 24.3 0.49 Berlin Germans 363 78.0 0.53 22.0 0.47 Poland Poles 88 79.4 0.54 21.6 0.46 New York Whites 74 82.4 0.58 17.6 0.42 Helsinki Finns 196 86.3 0.63 13.7 0.37 New Mexico American Indians 69 98.5 0.88 1.5 0.12 Utah American Indians 79 100.0 1.00 0 0 The alleles Se and se differ in the frequency and have an anthropological value. They occur in different frequency in different populations. They have a high frequency in the American Indiana and a low frequency in the southern Indians. In US 20% of the population is secretors whereas 80% of the population consist of non-secretors. The fusion allele of the FUT2 (secretor type alpha(1,2)-fucosyltransferase) gene at a high frequency and a new se385 allele in a Korean population SECRETOR AND NON-SECRETOR A person secreting blood group antigens into the body fluids and other secretions like saliva, semen, tear, mucous in the digestive tract and respiratory cavities are named as secretors. In similar terms they put their blood type antigens in the body fluids. They secrete antigens according to their blood type, A secrete antigen A and H, B secret antigen B and H, O secrete antigen O and AB secrete A, B and H antigen. Secretors expresses Lewis b (Leb) antigens on the RBC where as non-secretor expresses Lewis a (Le a) on their RBC.These antigens in the body fluids give additional protection to the individual against the various microorganisms and the lectins present all around us. 15- 20% of the population consists of non-secretor. These individual fail to secrete the blood group antigens in their body fluids hence they become susceptible to bacterial and superficial yeast infections. A large no of them sometimes also suffer from the autoimmune disorder. This could also be correlated with the secretor and non-secretor phenotype. The body secretions of secretors and non-secretors differ quantitatively and also qualitatively. The type and quantity of the antigens present in it differ among different individuals. In some cases the non-secretors may contain the A and B antigens in the saliva but the quantity is less and even quality is very low hence they have similar functional problem. There are certain properties which are specific for secretors and differ in non-secretors. Some are listed below: Intestinal alkaline phosphatase activity ABH secretor correlates the activity of alkaline phosphatase and serum alkaline phosphatase present in the intestine. Non-secretors have low activity of alkaline phosphatase and serum alkaline phosphatase which is responsible for the breakdown of fat and assimilate calcium.2-5 Low molecular weight alkaline is present in both secretors and non-secretors and high molecular weight alkaline phosphatase is present only is secretors.6 Bacterial flora The ABH blood types influence the population of bacteria residing in the local vicinity of the gut mucin glycoproteins. Bacteria produce enzymes that have the capability to degrade the end sugar of A, B, and H blood antigens and which are consumed as food by them. The B antigen degrading bacteria produce enzyme to remove the end alpha-D-galactose and A antigen degrading bacteria produce enzyme to detach N-acetylgalactosamine which are used as a source of food by them.7,8 Blood clotting The secretor and the ABO genetics influence each other and effect upto 60% of the vWf concentration variation in plasma. Raised levels of factor VIII and vWf may cause thrombotic and heart disease in future. Secretors have the slowest clotting time, thinnest blood, least tendency of platelet aggregation, low amount of factor VIII and von Willebrand factor (vWf).9,10 The non-secretors have highest clotting time, thick blood, high amount of factor VIII and von Willebrand factor (vWf) and low bleeding time. The blood viscosity is also influenced by the secretor status of that individual. Phenotype Lewis Characteristics of Clotting Le (a- b-)  Ã‚  maximum action of factor VIII and vWf Very Low bleeding times (seen in A, B and AB) Le (a+ b-) intermediary action Low bleeding times (seen in O) Le (a- b+) minimum action of factor VIII and vWf Very Long bleeding times (seen in O) Blood Type Lewis and Factors effect Blood Clotting Immunoglobulin Variations ABH non-secretors express low concentration of IgG immunoglobulin.11,12 The secretion of varying concentration of diverse constituents of the blood group is controlled by the secretor gene and it also affects the phagocytic activity of the leucocytes which provides an added advantage to the non-secretors. The leucocytes of the non-secretors possess a greater ingestion power when compared to the secretors. The O and B blood group non-secretors have the highest phagocytic activity.13 The presence of different concentration of anti-I in the an individuals serum is affected by the ABO group, secretor status and sex of the individual. The secretors females have a high level of anti-I in the serum as compared to the males.14 The non-secretor have low levels of IgA and IgG antibodies and hence have frequent problems with the heart valve. Genetics and Biochemical pathways The secretion of the blood group antigens in the body fluids and other secretions are genetically influenced by certain allelomorphic genes. Secretor gene contains two alleles (Se) and (se). The dominant gene (Se) is present in the homozygous or heterozygous condition in the secretors which lead to the secretion of antigens into the body fluids. (se) is recessive allele and is present in non-secretors in the homozygous condition. SeSe and seSe produces a dominant secretor phenotype and sese produces a recessive non-secretor phenotype. Basically three genes are responsible for the formation of the A and B antigens. They are namely ABO, Hh, and Sese genes encoding glycosyltransferases which produces the A and B antigens. H antigen present in the individual with O blood group is the precursor for the formation of A and B antigens. H antigen acts as a backbone for A and B antigens. The O gene is considered as amorphic. The allele Hh and Sese reside on each locus and are closely linked together. It is also suggested that one of the allele has arisen by the gene duplication of the other. The second allele on the same locus is really rare. The product related to this allele hasnt been discovered yet and hence it is considered as amorph. The oligosaccharide responsible for the formation of the A and B antigen can exist in a simple linear fashion or a complex branched fashion. Infants A, B and H antigens contain high amount of linear chained oligosaccharide whereas oligosaccharides present in an adult contain high amount of branched chained oligosaccharides.15 The A and B antigen is synthesized from a common intermediate known as substance H. The conversion is carried out by the addition of a sugar molecule to the non reducing end of the H oligosaccharide chains. This addition affects the reactivity of H antigen.16,17 The ABH substances are secreted in the Urinary respiratory tract, gastrointestinal tract by mucous glands residing there. The secretor gene regulates the synthesis of blood group antigens in the glands of small intestinal mucosa. The secretors and non-secretors produce A and B substances which are basically glycoproteins in pylorus and Brunners glands and produce A and B substances those are soluble in alcohol and glycosphingolipids in nature.18,19,20 The secretors also produce ABH substances in the prostate and lactating mammary glands.20 The secretion of breast is rich in H substance but poor in substance A and virtually absent in substance B. The synthesis of these constituents in the pancreas and secretory cells of sweat gland is not controlled by the secretor gene.21 The blood groups substances were also found in the calyxes and collecting tubules of the secretors (Se) but it could not be concluded that whether they are produced by the kidneys or are generally excreted. These secretions were noticed in the eight to nine weeks old salivary glands and stomach and later it appears throughout the gastrointestinal tract.19,22 Glycosphingolipids carrying the A or B oligosaccharides are present on the membranes of RBCs, epithelial and endothelial cells and are also present in the plasma in the soluble form. The glycoproteins carrying the similar A and B oligosaccharides are responsible for their activity in the body fluids. In the body fluids they are present in the secreted form. The A and B oligosaccharides which do not contain the carrier proteins are present in the milk and urine. The chromosome 19 contains FUT 1 and FUT 2 genes which code for fucosyltransferase.23 FUT genes numbered from 1-7 and form clusters which are responsible for the production of enzymes called as fucosyltranferases. The cluster is located on chromosome 19q13.3. Fucosyltranferase helps in the formation of fucose moiety which is added to the H antigen and further gylcosylate the A or/and B antigens.24,25 H antigen is a basic blood group antigen present in each and every human being but the content varies in different individuals of the same ABO group. A general pattern indicates that its strength varies as O>A2>A2B>B>A1>A1B. Water soluble H antigen has been demonstrated in the saliva and the body fluids of the individuals. H antigens are fucose containing glycan units which are present on the glycolipids or glycoproteins residing on the erythrocytes membrane or in the secretions. The fucosylatedglycans are the substrate for the enzyme glycosytransferases that are responsible for the formation of the Lewis and A, B blood group antigen epitopes. Secretors contain both the alleles whereas non secretor contains the null allele for FUT2 gene. The FUT 2 gene codes for fucosyltranferaseenzyme in the exocrine tissues which lead to formation of antigens in the body secretions and body fluids. The A and B genes produce glycosyltranferase that add sugar to oligosaccharide chains that is converted to H antigen. The H antigen are constructed on the oligosaccharide chain. The oligosaccharide chains could be of two type: Type 1 and type 2.15 The glycosphingolipids present in the plasma and on the membranes of glandular and parenchymal cells and glycoproteins present on the cell surfaces or body fluids carry either the type 1 or type 2 chains. The glycolipids antigens present on the RBC contain type 2 chains. A gene encodes N-acetyl-galactosaminyl-transferase and B gene-encodes galactosaminyl-transferase and add   GalNAc   and  Gal   in alpha (1-3) linkages which is acts on the H gene transferase. The H gene produces fucosyltransferase that add fucose to the terminal Galactose molecule of type 2 chain. It forms an alpha (1-2) linkage. A and B antigens are constructed when the A and B transferases attach respective sugars to the type 1 or type 2 chain substituted with Fucose.26 The secretor gene FUT2 located at 19q13.3 and codes for the activity of the glycosyltransferasesin concert with the FUT1 gene coding for H antigen, needed to assemble both the ABO and Lewis blood group and are active in mucous gland and goblet cells which interact with each other and lead to secretions of antigens in the fluids. The expression patterns of both the genes are different. The FUT1 (H) gene is dominantly expressed in the erythroid tissues which lead to the formation of the H enzyme whereas the FUT2 (secretor) gene is expressed in the secretory tissues and lead to the formation of secretor enzyme. The product of the H enzyme or H gene resides on the erythrocytes and product of secretor gene resides on mucins in secretions. If an individual lack these alleles, he/she will not be able to express the above active enzymes therefore they would be deficient of the substrates which are required by the A or B glycosyltransferases. Therefore they would not express the A and B epitopes. Correlation between Lewis Phenotype and ABH Secretor status The Lewis typing also helps in finding the ABH secretor status. The production of Lewis antigens is genetically controlled. Individuals possessing the Lewis (Le) gene would produce the Lewis antigens which are carried in the plasma by different substances and are absorbed onto the Red blood Cells present in ones blood. The ABO determinants and H/h blood groups factors seem to show structurally corelation to Lewis blood determinants. FUT1 provide the glycans for glycosyltransferases which convert Lewis antigen to ABH antigens. FUT2 allele is expressed in the secretor and is responsible for the expression of type1 H determinant. The secretors convert their Lewis a antigen to Lewis b therefore they are (a-b+) and the non-secretor are (a+b-) as they lack the FUT2 responsible for glycosyltransferase which could convert Lewis a antigen to Lewis b antigen. Lewis (Le) gene and Secreting (Se) gene interact with each other. Initially Lewisais formed and if Se gene is absent in an individual the Lewisa substance is absorbed on the RBC and the individual is typed as Lewisa but in secretors the Se gene controls the activation of the H gene which causes addition of an additional sugar to Lewisa which convert it to Lewisb. Secretors contain both Lewisa and Lewisb in their plasma but absorb Lewisb preferentially on the red blood cells and the individual is typed as Lewisb. Hence we could interpret that presence of Lewis gene would type an individual as Lewisa positive or Lewisb negative or vice versa. An individual could not be positive for both. A person containing both Lewis gene and Secreting gene are typed as Lewisa negative and Lewisb positive whereas a person having the Lewis gene but not the secretor gene is typed as Lewisa positive and Lewisb negative. Individual who does not have Lewis gene regardless of secretor gene is typed as Lewisa negative and Lewisb negative.27,28 Note: Lewis Double Negative (LDN) is a sub type of non secretors but Lewis typing cannot be used for them to determine the ABH secretor status. Detection methods29-31 The presence and absence of the antigens in the body fluids could be detected by Agglutination Inhibition and Lewis typing. Agglutination Inhibition test could be divided into two parts:- Part I Antibody Neutralization: To determining ones secretor status, the saliva of the individual is mixed by the antiserum (Anti-A, Anti-B or Anti-H) available commercially. In secretors the soluble substances i.e. blood group antigens will react with the antibodies present in the antiserum and will get neutralized. Part II Agglutination Inhibition: The bed blood cells obtained commercially are added to the test mixture. In secretors agglutination of the RBC do not take place as no free antibodies are available to agglutinate them. All the antibodies have reacted with the soluble antigens present in the saliva whereas in non-secretors agglutination would occur upon addition of the RBC as no blood group antigens are present in the saliva so antibodies present in the antiserum are not neutralized and hence would be free to react with the test RBC cells which are added to the test mixture. Hence agglutination is a negative test for secretor status and positive test for the non-secretor status. Note: Anti-H lectin containing phytohaemagglutinin virtually specific for human RBC. Thirteen Cucurbitaceaespecies have been investigated for the anti-H activity present in their seed lectins. Lectins has been extracted and purified from Ulexeuropaeus seeds. It could be used to demonstrate the H secretor status of blood group O individual and also for subgrouping the blood group A individuals. Lewis typing: Individuals carrying the Lewis gene produce Lewis antigens that are carried by the plasma and are also adsorbed on the red blood cells. Lewis antigens do not reside only on the red blood cells. Initially the gene gives rise to Lewisa. If Se gene is present it activates H gene which interact with the Lewisa and add a sugar to Lewisa and hence get converted it to Lewisb. Both Lewisa and Lewisb in present in the plasma of the secretors. If the Se gene is not present then the Lewisa substance is adsorbed on the red cells and individuals are typed as Lewisa. The secretor status of an individual could be determined with help of Lewisa and Lewisb antibodies mixed with an individuals saliva and observing the agglutination macroscopically. Disease Susceptibility among Secretors and Non-secretors Digestive system Non-secretors are more prone to the diseases caused by the oral bacteria in the digestive system of an individual. It includes ulcers, celiac diseases gastric carcinoma pernicious anemia etc. It could lead to dysplasia or increase in the number of cavities present in the digestive tract. Non-secretors are less resistant to the infection caused by Helicobacter pylori which could lead to the formation of peptic and duodenal ulcers.32,33 It could easily colonize and cause inflammation in the non-secretors.34 The non-secretors lack the blood group antigens in the mucus secretions therefore H.pylori attach to the walls of the digestive tract and cause infection. The secretors have a tendency to secrete free ABH antigens in their intestinal secretions which effect the bacterial and lectins adherence to the microvilli present in the gut. The secretors produce these antigens and prevent H.pylori attachment. These antigens act as a decoy in the secretors which prevent them from attaching with the host tissues. The non-secretors also show a lower IgG immune response to the H.pylori. They have extreme rate of bleeding and stomach ulcers but correlation between these complications and the secretor status have not been documented yet. The non-secretors are not able to turn off the digestive enzymes and hence they produce large amount of enzyme pepsin and hence are more prone to duodenal ulcers. 50% of the duodenal ulcers are present in non-secretors. 30-40% of group O individuals are affected by the duodenal ulcers and 15- 20 % are affected by the gastric ulcers. They show a high risk factor along with the gene coding for hyperpepsinogenemia I which impact in the risk of duodenal ulcers.35,36 Group A individuals have a higher tendency of having gastric cancer and pernicious anemia. Statistics shows that 20% of the group A individuals are affected by gastric cancers and 25% are affected by the pernicious anemia. Oral pathology The non-secretors are more prone to oral diseases like mouth and esophagus cancer, epithelial dysplasia etc. They have more cavities than secretors.37 Diabetes The ABH non-secretors and Lewis negative (Le a-b-) individuals have a high risk of developing insulin dependent diabetes or complications arising from diabetes.38,39 Secretors with juvenile diabetes have a low chance of developing retinopathy.40 The ABH non secretors which are affected by insulin dependent diabetes mellitus, they show mean levels of C3c and C4 is lower as compared to ABH secretors. Metabolic Syndrome X The Lewis negative men are predisposing to syndrome X and prothrombic metabolism. They have high levels of BMI, SBP, triglycerides and low levels of insulin in serum and plasma glucose while fasting. This relationship is not true for women and is only applicable for the men.41-43 Respiratory System   Secretors have an added protection against the harmful environmental assaults directed towards our lungs and as usual non-secretors have a health disadvantage. They are over represented among the people suffering from influenza viruses A and B, rhinoviruses, respiratory synsytial virus and echinoviruses.44 Secretors who are miners or smokers do receive a protection against the disastrous effects of the cigarette smoking. Asthma is very common among the individuals working in the coal mines. Upon research it was concluded that asthma among them is also related to the non-secretor phenotype present in them. The non-secretor has a tendency to snore and are more prone to COPD (Chronic Obstructive Pulmonary Disease).45 Heart disease The ABH non-secretor phenotype have a high risk of developing myocardial infarction and Lewis negative individuals have a high risk of developing chronic heart disease (CHD) and also ischemic heart disease (IHD).46 They contain high levels of triglycerides.47 Alcoholism has a positive interaction with the Lewis negative individuals. Alcohol consumption is protective in these individuals.48,49 Autoimmune Disease   Autoimmune disorders such as Sjogrens syndrome, spondylitis, sclerosis, arthropathy, arthritis, and Graves disease are more prone in non-secretors.50-52 The ABH non-secretors affected with graves disease produces high levels of antitubulin antibodies as compared to secretors and are unable to produce the water soluble glycoproteins in the saliva.53 Fetal Loss and Infertility ABO antigens are also found on the sperm of the secretors.54 These are obtained from the seminal secretions present in them. ABO incompatibility could exist between the wife and husband if could affect the fertility of an individual.55,56 This issue has not been properly studied and is therefore under research. Rheumatic Fever The secretors and group O individuals are resistant to Rheumatic fever and more number of cases have been recorded in the non-secretors.57,58 Secretor status could also determine whether the rheumatic fever would be followed by streptococcal pharyngitis or not.59-61 Neisseria species The non-secretors who do not produce water soluble antigens in the saliva are at the risk of getting infected by Neisseria meningcococcal disease.62 The immune capabilities of the secretor provide a relative protection in the secretors. The ABH non-secretors produce low level of anti-meningococcal salivary IgM antibodies which provide protection to the secretors against the microorganism.63 Candida species Non-secretors are barriers of candida species and therefore are frequently affected by the candida infections. The glycocompounds secreted by secretors in the body fluids inhibit adhesins present on the yeast which are responsible for their adhesion with the body tissues.64-66 This leads to the development of the chronic hyperplastic Candidiasis. Statistics shows that 68% on the non-secretors are affected by chronic hyperplastic candidiasis.67 Non-secretor women are affected by recurrent idiopathic vulvovaginal Candidiasis. An individual with a combination of non-secretors and absence of Lewis gene are at relative risk of developing recurrent idiopathic vulvovaginal Candidiasis.68 Tumor Markers The individuals with homozygous active Le alleles (Le/Le) and inactive (se/se) alleles shows a highest mean value of CA19-9 tumor marker.69 The Lewis negative individuals irrespective of Se genotype have negative values for CA19-9. The Lewis negative individuals have higher mean value for DU PAN-2 as compared to Le-positive individuals.70 We can conclude that CA 19-9 marker is not an appropriate tumor marker for Le-negative individuals but DU-PAN-9 is an appropriate tumor marker.71 UTI Non-secretors show a higher risk of getting recurrent urinary tract infection (UTI) and renal scars as compared to secretors. This susceptibility is higher among negative Lewis subset. Statistics of a study done on women affected with recurrent urinary tract infection stated that 29% of the non-secretor women were affected by UTI and 26% of Lewis (a-b-) women were affected by the UTI.72-74 The non-secretor phenotype and blood group B and AB phenotype work together to increase the risk of UTI among women. Women and children suffering from renal scarring with and without the antibiotic treatment for UTI are prone to UTI and pyelonephritis.75-77 55-60% of non-secretors develop renal scars and 16% on secretors develop renal scars.78 C-reactive protein levels, erythrocyte sedimentation rate and body temperature are higher in the non-secretors that in secretors with recurrent UTI.79 Conclusion It concludes that there exist a statistical association between the individuals blood-group secretor phenotype and the diseases they are susceptible to. So knowing your secretor status is advantageous as we can use the nutritional supplements more intelligently and effectively. It also makes us aware of the diseases, illness and metabolic dysfunction we are prone to, difference in the levels of intestinal alkaline phosphatase activity, propensities towards blood clotting, tumor markers and different ingredients of breast milk so that we can manage them before hand and would be prepared for them in the near future.

Women Online :: Internet Feminist Technology Essays

Women Online Is it better to be a woman online or a man online? Which sex is more respected? Do women have better conversations then men or is it the other way around? Can women participate in a debate with men and still be heard? Are women being treated equally online in comparison to their male counterparts? These are some of the questions that are asked in the articles of Dale Spender and Laura Miller. Dale Spenders article entitled Gender-Bending, and Laura Millers article entitled Women and Children First: Gender and the Settling of the Electronic Frontier. In which the two female authors give their opinions about the good side and bad side of being a woman online. In Dale Spenders article she describes how womens behaviors alter depending on if they are talking to a man or a woman. Their behaviors alter by the terms and tones they use to their posture/demeanor and weather or not eye contact is made. Spender observed such behavior in a study she preformed. When a man entered a conversation uninvited women would automatically give him the floor, as was to be expected. But what wasnt expected was that women would change the way they were sitting and they would look up to him rather then down. In another experiment a baby was handed to a group of women with its sex unidentified. When the sex was identified as a female the baby was held closely and tightly. The females heads were bent down and they spoke quietly and soothingly to the baby. When the women where told that a mistake was made that the baby was in fact a boy the behavior altered. At some points the baby was almost dropped when the women changed the way the baby was being held. The baby was held further away and was bounced up and down. The womens tone changed from soothing to loud and robust. The child was also raised to eye-level when talked to. Even in the case of babies Spender believes that all of our words, actions, and body language are gender-loaded(71). She believes that only when we know the sex of who we are talking to can we actually conduct a conversation. Due to these studies and experiments Spender came to the conclusion that the only way to gain respect is to be a man. Not only when we are young but in writing and conversation.

Clinical Manifestation of HIV Infection Essay

There are lots of diseases that are transmittable and dangerous to human lives but until today the HIV still leading the most dangerous human life taker. Human Immunodeficiency Virus (HIV) destroys the immune system’s helper T cells, the loss of which causes AIDS. The person infected called as HIV positive that shows by test for antibodies to HIV in the bloodstream to be infected with HIV. But how you will know a person if she/he is infected. What are the manifestations you can observe? How can this be applied scientifically based knowledge to nursing practice? What knowledge do you get in reading all these articles?  Ã‚   In the next paragraph the answers to the question are discuss step-by-step. Clinical Manifestation The incubation period of a few weeks after exposure to HIV, most infected individuals present with an acute flue-like illness. The clinical symptoms of HIV infection were first descried in 1985 as an illness resembling infectious mononucleosis. The most common symptoms are fever, maculopopular rash, oral ulcers, lymphaenopathy, arthralgia, pharyngitis, malaise, weight loss, aseptic meningitis and myalgia. In one study, fever (80%) and malaise (68%) had the highest sensitivity for clinical diagnosis of HIV infection, whereas loss of weight (86%) and oral ulcers (85%) had the highest specificity. In the study, the symptoms of fever and rash followed by oral ulcers and pharyngitis had the highest positive pr5edictivevalue for diagnosis of HIV infection. In another study, fever, rash myalgia, arthritis and night sweats were the best predictors for HIV infection.   The symptom phase of HIV infection lasts between 7-10 days, and rarely longer than 14 days. The nonspecific nature of the symptoms posses a great challenge to the clinician and underlines the importance of a detailed history of exposure. (Altfeld & Walker). Another manifestation is Erythema elevatum diutinum (EED) is a chronic and rare dermatosis that is considered to be a variant of leucotoclastic vaculitis. The clinical manifestations are papules, plaques or nodules, which vary in coloration from reddish to purple, light brown and sometimes yellowish. The lesion’s are persistent and symmetrically distributed on extensors surfaces, particularly in the joints of the extremities. Such patients may presents arthralgia. The itchiness and pains, with rare systemic involvement were also observed (Medical Journal 2005). Immune thrombocytopenic purpura may be the sole clinical manifestation of HIV infection. Results of the treatment of 6 patients spontaneous bleeding due to severe thrombocytopenia are presented.   In all patients immune thrombocytopenic purpura was the only clinical manifestation of HIV infection. Four of them were intravenous narcotic addicts, and the other two patients did not belong to high-risk groups (Elizovic, Jevtovic &Rolovic 1989). Peripheral Facial paralysis as a manifestation of HIV Infection, Two patients had typical Bell’s palsy while one had a facialdiplegia. CD4 cell counts were above 100 cells/mm3 in all cases. A review of literature confirmed that peripheral facial nerve palsy could occur at any stage of HIV infection and in various clinical contexts. It is suggested that adult patients presenting with peripheral facial paralysis should be counseled, and screened for HIV (Annals AF Med: 2002 1(1) 1:28-30).

Famous Inventors from New Mexico

Famous Inventors from New Mexico A few famous inventors have hailed from New Mexico. William Hanna William Hanna (1910 - 2001) was one-half of Hanna-Barbara, the animation studio behind such famous cartoons as Scooby-Doo, Super Friends, Yogi Bear and The Flintstones. In addition to co-founding the studio and being the creative force behind many of its most famous cartoons, Hanna and Barbara were also responsible for creating Tom and Jerry early in their careers. Hanna was born in Melrose, New Mexico, though his family moved several times throughout his childhood. Edward Uhler Condon Edward Uhler Condon (1902 – 1974) was a nuclear physicist and a pioneer in quantum mechanics. He was born in Alamogordo, New Mexico, and while he attended high school and college in California, he returned to the state for a brief tenure with the Manhattan Project during World War II. As research director for Westinghouse Electric, he oversaw and conducted research that was instrumental to the development of both radar and nuclear weapons. He later became National Bureau of Standards, where he became a target for the House Un-American Activities Committee; however, he was famously defended against these allegations by such figures as Harry Truman and Albert Einstein. Jeff Bezos Jeff Bezos was born in Albuquerque, New Mexico on January 12, 1964. Hes best known as the founder, chairman and CEO of Amazon.com, making him one of the pioneers of e-commerce. He also founded Blue Origin, a private spaceflight company. Smokey Bear While not an inventor in the traditional sense, the living symbol of Smokey Bear was a native of New Mexico. The bear cub was rescued from a 1950 wildfire in the Capitan Mountains of New Mexico and nicknamed Hotfoot Teddy due to the injuries he sustained during the fire, but renamed Smokey, after the fire prevention mascot mascot who had been created a few years prior.